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Abstract

“PROSPECTIVE OBSERVATIONAL STUDY ON THE OUTCOME AND ADVERSE DRUG REACTION OF BOTULINUM TOXIN INJECTION IN WRITER’S CRAMP PATIENTS IN A TERTIARY CARE HOSPITAL”

Sruthy S. A.*, Dr. Thomas Iype and Jayakrishnan S. S.

ABSTRACT

Writer's cramp is a form of task specific focal dystonia. It is common among Indian population but considered as a rare condition. Out of different dystonic disorders, Writer’s cramp is the most prevalent one. When comparing the males to females ratio, females are the most affected population but due to the unawareness about the condition males are came for treatment probably. The main treatment strategy for the particular condition is Botulinum toxin. Thus, results from this study will help to identify the outcome and the adverse drug reaction of the botulinum toxin injection to the patient population affected with writer’s cramp condition. Primary objective is to determine the outcome of botulinum toxin injection before and after in writer’s cramp patients and to determine the ADR related to BTX injection. Study was carried out in a Tertiary care setting, Department of Neurology, Govt. Medical College Hospital, Thiruvananthapuram with a sample population 25. Majority of the writer’s cramp patients were predominantly affected with flexor type (68.0%). Most of the patient population in the study was found to be from urban areas (68.0%), about 72% of population was males and of the age about 21-50 years. Duration of illness experienced for patients were less than 6 months (32.0%) with less pain, tremor and jerking. Most of the affected patients were taking the botulinum toxin injection and after the review the outcome was measured and it was found to be botulinum toxin injection is preferably effective to the patients suffering from writer’s cramp. The Adverse Drug Reaction were assessed using Naranjo Adverse Drug Reaction Scale and found that majority of the patients reported with probable ADR (64%). The probability value determined as p< 0.001 which is functionally normal. Financial problems and lack of knowledge about the condition and its treatment were the next two important barriers of study. From this the effectiveness of botulinum toxin injection towards the Writer’s Cramp patients seems o be significantly improved.

Keywords: ADR, BTX, Injection, Pain, Writer’s Cramp.


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