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Abstract

FORMULATION & EVALUATION OF ACYCLOVIR MICROBEADS

Syed Gouse Firoz*, Jyoti Sahu and Fatima Shireen

ABSTRACT

The present study is concerned with the formulation and evaluation of
acyclovir microbeads in the presence of polymer. Acyclovir drug is an
antiviral drug which is preferentially taken up by the virus infected
cells and thus it inhibits DNA synthesis and viral replication but only
20 percent of oral dose is absorbed as it is having less plasma protein
bounding and having t ½ life is 2-3 hours. Microbeads are prepared to
overcome its less oral absorbent to obtain prolonged controlled drug
delivery, to improve bioavailability or stability of drug. This article
contains different concentration of polymer (Chitosan and sodium
alginate) and excipients to prepare Acyclovir microbeads which increase bioavailability by
increasing t ½ life elimination i.e maximum up to 12 hours.

Keywords: .


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