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Chandrakala Parajuli* and Prof. Dr. Dharma Prasad Khanal


This study was carried out to investigate phytochemical and biological study of Aleuritopteris anceps, also known as Rani sinka. The whole plant was collected from Kathmandu and Lalitpur district about 1300 m altitude in june-july and subjected to hexane, ethyl acetate and methanol extraction by maceration process. The phytochemical study revealed the presence of alkaloids, saponins, glycosides, terpenoids, tannins, carbohydrates and phenols. The biological study was done for antioxidant (by DPPH scavenging method), antimicrobial sensitivity test (by cup plate method) and anti-diabetic activity (by oral glucose tolerance test in glucose loaded rats). Antioxidant activity was considerable with IC50 value 29.22 μg/ml, 147.48 μg/ml and 453.67μg/ml methanol, ethyl acetate and hexane respectively. Antimicrobial activity was considerable to Gram positive bacteria Staphylococcus aureus and Bacillus cereus Gram negative bacteria Salmonella typhi but not at the concentrations of 100 mg/ml against Escherichia coli. The hypoglycemic effect of 200 mg/kg and 400mg/kg methanol extract was found to be 26.23% and 26.79% respectively where as standard drug Glimeperide showed 32.52%. This study concludes that it could serve as a source of potent antioxidant, antimicrobial and anti-diabetic agents. Therefore this study can be basis for the further research to find out more detail information regarding the relationship between antioxidant activity and other phytochemical content which may help to highlight the chemicals which are responsible for this activity.

Keywords: Aleuritopteris anceps, Rani sinka, Antioxidant activity, Antimicrobial activity, Anti- diabetic activity.

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