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Abstract

FORMULATION AND EVALUATION OF ZOLPIDEM NASAL IN SITU GEL

L. Karpagavalli*, K. Gopalasrsatheeskumar, N. Narayanan, A. Maheswaran, A. Isakki Raj and J. Hari Priya

ABSTRACT

In this work, Zolpidem nasal in situ gel was prepared and evaluated. TheZolpidem nasal in situgel were prepared by Temperature induced InSitu gelling system using various concentrations of carbopol934p and poloxamer(F1-F6). The prepared nasal in situgel were characterized for its Appearance,Viscosity, pH, Drug content, Gelation temperature, Gel strength, Mucoadhesive strength, and invitro drug release profile. The preformulation study results confirmed the compatibility between the drug and other excipients used in the formulation. The optimized formulation was selected based on itsgood gelation temperature and gel strength and invitro drug release profile. Thus it can be concluded that nasal in situ gel containing (F4) 0.5%carbopol&18%poloxamer concentration is an ideal gel for controlled and sustained nasal drug delivery system.

Keywords: Zolpidem, Carbopol934p, Poloxamer, insitu, Gel strength, Hypnotic.


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