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Abstract

DEVELOPMENT AND EVALUATION OF ELEMENTARY OSMOTIC PUMP TABLETS BEARING ANTIDIABETIC DRUG

Pranav K. Upadhyay* and Alok Mukerjee

ABSTRACT

An elementary osmotic pump (EOP) system that could deliver Glipizide (GZ) simultaneously for extended periods of time was developed in order to reduce the problems of type 2 non-insulindependent diabetes mellitus. In general, poorly water-soluble drugs is not good candidates for elementary osmotic delivery. However, GZ is a water-insoluble drug with a low dose (5 mg) so it is a great challenge to pharmacists to provide satisfactory extended release of GZ. GZ entrapped beta cyclodextrin it enhance the solubility of GZ. In present study, effect of appropriate amount of osmogents, plasticizer, and drug polymer ratio were optimized. One optimized formulation was selected for further evaluation. Different dissolution models were applied to drug release data in order to establish release mechanism and kinetics criteria for selecting the most appropriate model was based on best goodness of fit and smallest sum of squared residuals.

Keywords: Elementary osmotic pump tablets, Controlled release, ?- cyclodextrin, Glipizide.


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