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Abstract

ANTIDIABETIC ACTIVITY OF DRY EXTRACTS OF SWIETENIA MAHAGONI SEEDS IN ALLOXAN-INDUCED DIABETIC BALB/C

Sukardiman*, Novia Pegin, Herra Studiawan and Lusiana Arifianti

ABSTRACT

Objective: The present study was carried out to evaluate the antidiabetic activity of dry extracts of Swietenia mahagoni seeds Methods: Antidiabetic was induced experimentally by a single intraperitoneal administration of 3,8 mg/20 g body weight of Alloxanmonohydrat in each male mice. Three days after alloxan administration, blood glucose level was measured using a glucometer. Mice with blood glucose levels above 200 mg/dL were considered diabetic and were used in this study. Then the mice were randomly divided into five experimental groups of six mice each. First group as positive control (Glibenclamide 0,06 mg/20 g body weight). Second group as negative control (CMC-Na 0.5%). Samples were given by oral route at three dosage levels (10mg / 20g, 20mg / 20g and 40mg / 20g body weight). After treatment finished, blood sampling was done by sterilizing the tail with alcohol and then nipping the tail at the start of the experiment and this was repeated after 2nd, 4th, 6th and 24th h. Results: Oral administration of dry extracts of Swietenia mahagoni seeds at doses of 10, 20 and 40 mg/20g body weight demonstrated antidiabetic activity in a dose independent manner comparable to that demonstrated by glibenclamide at 3 mg/kg body weight from two second to the twenty-fourth hour. Conclusion: From the studies it is concluded that, dry extract of Swietenia mahagoni seeds is suitable to prepare formulation for treatment of diabetic.

Keywords: Diabetes mellitus, Antidiabetic activity, Swietenia mahagoni seeds dry extract, alloxan.


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