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Abstract

A FACILE SYNTHESIS AND IN VITRO BIOLOGICAL EVALUATION OF A SERIES OF SUBSTITUTED BENZOFURANS AS ANTITUBERCULAR AGENTS

Mahendar Gantala*, Dr. Mahesh Reddy Ghanta and Dr. Vasantha Mittapelli

ABSTRACT

We have prepared a series of some benzofuran substituted chalcones (2a-d) and their heterocyclic analogs such as isoxazolines (3a-d), pyrimidines (4a-d), pyrazolines (5a-d), benzodiazepines (6a-d) and benzothiazepines (7a-d) respectively, have been synthesised via ultrasound-promoted irradiation (20 kHz) and characterized by using physical and spectral analytical data. Further these compounds were evaluated for their in vitro antitubercular activity using Alamar blue assay.

Keywords: Chalcone, Isoxazoline, Pyrimidine, Pyrazoline, Benzodiazepine, Benzothiazepine.


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