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Abstract

A STUDY ON POLY PHARMACY CAN CAUSE DRUG-DRUG INTERACTIONS AND ITS SEVERITY ANALYSIS AMONG PATIENTS ADMITTED IN GENERAL MEDICINE & CCU OF A TERTIARY CARE HOSPITAL IN EASTERN INDIA.

Tanmoy Mukhopadhyay, Dr. Arpan Dutta Roy, Dr. Suchanda Gadre and Dr. T.
K.Chatterjee

ABSTRACT

An interaction is said to occur when the effects of one drug are changed by the presence of another drug. . Much more colourful and informal definitions by patients are that it is “when medicines fight each other.”, or“when medicines fizz together in the stomach”, or “what hap pens when one medicine falls out with another”[1] Appropriate drug utilization is beneficial in global reduction of morbidity and mortality with its consequent medical, social and economic benefits. Drugs are most common medical investions for betterment of patient but it had recognized long ago that they are fatal too. More correctly about drugs that “Drug are Double Edged Weapons. Inappropriate prescription of drugs is the major problem of health care system. Poly pharmacy is defined as concurrent use of multiple medication>2 by a patient. Poly pharmacy is a common occurrence in adult patients and mainly in elderly due to increasing comorbid diseases, availability of non-prescription drugs, hoarding of old medications, inadequate patient knowledge about medications and medical condition. The use of multiple medications increases the possibility of drug interaction and adverse reaction to drugs, poorer compliance, increased risk of hospitalization and medical error caused by drugs.[2] Critical care unit (CCU) patients are specially at increased risk to the development of druginteractions and this condition is complicated by disease severity and organ failure, both of which can alter the pharmacologic response to medications.[3,4] The number of prescribed drugs is another risk factor for the occurrence of DDIs. Studies have demonstrated a positive correlation between polypharmacy and DDIs.[5] It is believed that the potential for drug-drug interaction reaches 100% when the number of drugs prescribed reaches eight.[6]

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