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Abstract

COMPARATIVE STUDY BETWEEN ANJANA AND GHRITAPAAN IN THE MANAGEMENT OF SUSHKAKSHIPAKA (DRY EYE SYNDROME)

Nikita Baghel*, Shamsa Fiaz and Prabhakar Vardhan

ABSTRACT

Objective: Compare the clinical efficacy of Haridradi anjana and Vibhitakadi ghrita in the management of Sushkakshipaka (Dry Eye Syndrome). Methods: Ayurvedic formulations (Haridradi anjana and Vibhitakadi ghrita) were evaluated in a randomized, open lable pre and post trial study. four-arm, multicentre equivalence drug trial of 15 days dur- ation. A total of 40 eligible patients suffering from symptomatic Sushkakshipaka were enrolled and divided into 2 groups and monitored as per protocol. Results: Differences between the intervention arms for mean changes in primary efficacy variables were within the equivalence range by intent-to-treat and per protocol analysis. Statistically Extremely Significant relief were found in FBS, Burning sensation, Mucoid discharge, Dryness, Conjunctival congestion, Schirmer -1 test, TBUT ect in Group I and Statistically Extreamly Significant relief were found in FBS, Mucoid discharge, Dryness, Conjunctival congestion, TBUT and Tear Meniscus in Group II. Other adverse events were mild and did not differ by intervention. Conclusion: In this 45 days trial study of Sushkakshipaka, Ayurvedic formulations (Haridradi anjana and Vibhitakadi ghrita) sig nificantly reduced Dryness and improved Tear production. The unexpected itching rise requires further safety assessment.

Keywords: Haridradi anjana, Vibhitakadi ghrita, Sushkakshipaka.


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