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Abstract

DESIGN AND EVALUATION OF CONTROLLED RELEASE BUOYANT FORMULATIONS OF SUMATRIPTAN BASED ON SUPER POROUS HYDROGEL COMPOSITES

D. Manasa*, D. Srinivas Rao, D. Varun and T.M. Pramod Kumar

ABSTRACT

Formulation of potent drug molecules as dosage form still draws continuous interest and challenges against its optimization towards pharmacokinetics parameters like absorption, bioavailability, onset of action, duration of action etc. The consistent maintenance of plasma drug concentration within the therapeutic level for prolonged periods of time has been persisting as a challenge to the pharmaceutical field. The conventional dosage forms are designed to be consumed by the patients two, three or even four times a day, which ultimately results in non compliance by the patient. The principal aim of an oral controlled release drug delivery system is to achieve better bioavailability and release of the drug from the system, in a predictable and reproducible manner. A number of controlled drug delivery systems have developed to prolong and control the release of drugs for a period of times in order to enhance their curing efficiencies. The main objectives are 1) The present research work aims to design and evaluate hydro dynamically balanced buoyant formulations of Sumatriptan based on Superporous hydrogels. 2) To carry out the drug-excipient compatibility studies. 3) To evaluate the drug release in developed formulations by in-vitro studies. The drugs with low biological half life and unstable in the small intestine are good candidates for Gastro retentive dosage forms.

Keywords: Pharmacokinetics, conventional dosage forms, Sumatriptan, Superporous hydrogels.


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