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Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF NARATRIPTAN HCl USING SUBLIMATION TECHNIQUE

Syed S M*, Farooqui Z S, Mohammed M, Shaikh A Y

ABSTRACT

The aim of current study was to formulate fast acting mouth dissolving tablet of Naratriptan HCl for the treatment of migraine in subject with a shortened time period for the onset and maximum peak concentration. Tablets were prepared by direct compression following sublimation camphor was used as a sublimating agent. Sodium starch glycolate and crospovidone were used as superdisintegrants in different concentrations. The prepared tablets were evaluated for thickness, uniformity of weight, content uniformity, hardness, friability, wetting time, water absorption ratio, in vitro disintegration time and in vitro drug release. The tablet disintegrates in vitro within 12-20 sec. Almost 90% of drug was released from most of the formulations within 15 min. The formulations containing 4% crospovidone was found to give the best results. From the results it was concluded that mouth dissolving tablet of Naratriptan by sublimation technique can be promising tool for delivery of Naratriptan in migraine.

Keywords: Naratriptan, Migraine, superdisintegrants, Sublimation


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