WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DEVELOPMENT AND EVALUATION OF LIQUISOLID COMPACTS OF FINASTERIDE

Mohd. Ateequoddin, D. Prasanthi, M. D. Faheemuddin, Md. Mazher Ahmed*, Mohammed Asadullah Jahangir and Md. Adil Ahmed

ABSTRACT

The aim of the present study was to improve the solubility of a poorly water soluble drug, Finasteride under BCS class II drug. Finasteride (FNS) is an antiandrogen which acts by inhibiting 5-alpha reductase, the enzyme that converts testosterone to dihydrotestosterone. It is used in benign prostatic hyperplasia (BPH) in low doses and in prostate cancer in higher doses. The term „liquisolid systems‟ (LS) is a powdered form of liquid drug formulated by converting liquid lipophilic drug or drug suspension or solution of water-insoluble solid drug in suitable non-volatile solvent systems into dry looking, nonadherent, free-flowing and readily compressible powdered mixtures by blending with selected carrier and coating materials. From non-volatile solvents such as PEG 400, 600, tween 80, glycerine, propylene glycol etc., Tween 80 is optimised and carrier materials such as starch, lactose, micro crystalline cellulose etc were used to formulate the liquisolid tablets in different ratios. The percentage release of the drug was increased by using tween 80 as non volatile solvent with carrier materials MCC Avicel 101, Avicel 102 and Aerosil 200 as a coating material. The ratio of (20:1) of both Avicel 101 and Avicel 102 formulation was found to be releasing 99% and 98% of the drug in 60 mins which is optimized with dissolution media as distilled water using USP ׀׀ apparatus at 50 rpm and absorbance were seen at 254 nm respectively. The Liquisolid tablets of Avicel 101 and Avicel 102 with (20:1) i.e carrier:coating ratio showed higher dissolution rate (98.75±0.21) and (99.25±0.35) when compare to marketed (43.49±0.26) and pure drug(17.77±0.22). Hence Tween 80 and Avicel 101, Avicel 102 were optimised non volatile solvent and carrier material in enhancing the dissolution rate of finasteride drug. FTIR and XRD studies showed no evidence of drug excipients interaction. Accelerated stability studies for 1 month indicated the tablets were stable.

Keywords: Finasteride, Liquisolid tablets, Tween 80, Avicel, Aerosil 200.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More