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Abstract

SYNTHESIS, ANTIMICROBIAL ACTIVITIES OF SOME NOVEL PYRIDINE AND PYRIMIDINE DERIVATIVES

Vinod Tukarama, Ketan Ganurea, Sheshikant B. U.b and K. S. Lohara*

ABSTRACT

The main aim of the work was to develop antimicrobial active compounds. As a part of systematic investigation of synthesis and biological activities of heterocyclic compounds containing pyrazole, quinoline, salicyaldehyde moieties linked to various heterocyclic systems. We have synthesized new compounds viz., 2-amino-4- (substituted)-6-phenylnicotinonitriles (3a-c), 4-(substituted)-6-phenyl- 1H-pyrazolo[3,4-b]pyridin-3-amines (4a-c) and 5-(substituted)-7- phenylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dithiones (5a-c). Structures of these compounds have been deduced upon the basis of elemental analysis and spectral data (IR, NMR and Mass). Antibacterial activity results revealed that, compounds 4a, 4b and 5a showed promising activity versus P. Aeruginosa, whereas antifungal activity results indicated that, compounds 4b, 5a and 5c exhibited maximum zone of inhibition against A. Niger.

Keywords: Pyrazole, quinoline, pyridine, pyridopyrimidine, pyrazolopyridine, antimicrobial.


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