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Abstract

FORMULATION AND EVALUATION OF REPEAT ACTION TABLETS OF ORLISTAT AND DROTAVERINE HYDROCHLORIDE

Dr. Shaik.Md.Zakir hussain* A.V.S.Ravi Sainadh, Dr. V. Sreenivasulu,  R.Naganjianyelu,  M.Sabareesh Reddy

ABSTRACT

Intensity of bioavailability of poorly soluble drug remains one of the most challenging aspects of drug development. This study was designed with an objective to obtain a better drug release profile of orlistat and drotaverine hydrochloride and good drug loading efficiencies by using various synthetic polymers such as HPMCE15 AND CMC at different proportions. The compatibility studies between drug and polymer was studied and followed by preformulation studies carried and finally they are formulated as tablets into different batches by using repeat action technique. It has been observed that the formulation of batch [F2] has shown good drug loading and better drug release compared to other batches. This work was done to decrease the adverse drug effect of orlistat i.e. pain in the stomach. Hence to overcome this problem Drotavarine hydrochloride has been selected as a model drug which is an anti spasmodic agent.

Keywords: Orlistat, Drotavarine hydrochloride, HPMCE15M, CMC


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