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Swati Sharma* and Dr. Jyoti Saxena


Objective: Paspalum scrobiculatum (P. scrobiculatum) is a millet variety, cultivated throughout India having different pharmacological properties like antidiabetic, anti-inflammatory, hopolipidaemic, antirheumatic and wound healing. Various bioactive components from plant origin are studied to access their role in neurodegenerative diseases. In this study, the antidepressant effect of ethanolic extract of P. scrobiculatum (EEPS) grains was studied in mice. Method: Forced swimming test (FST) and tail suspension test (TST) were used to determine the antidepressant effect of 200 and 400 mg/kg EEPS grain extracts by oral administration to mice. Imipramine (30 mg/kg) was used as standard drug. Result: The results showed that doses, 200 mg/kg and 400 mg/kg ethanolic extracts showed antidepressant effect by significantly reducing the immobility time compared to vehicle (P<0.001), in both the models studied, similar to that of standard imipramine drug. Significant variation in immobility time of 400 mg/kg ethanolic extract was observed. Conclusion: The findings suggest that grains of P. scrobiculatum millet exert antidepressant like behavior in mice, which can be attributed to the bioactive components present in the ethanolic extract of P. scrobiculatum, which are yet to be elucidated by fractionation studies.

Keywords: Depression, Forced swim test (FST), Immobility time, Paspalum scrobiculatum, Tail suspension test (TST).

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