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Abstract

STUDY TO EVALUATE SAFETY AND EFFICACY OF METFORMIN MONOTHERAPY AS COMPARED TO DUAL AND TRIPLE COMBINATION WITH SULPHONYLUREAS AND PIOGLITAZONE IN TYPE 2 DIABETES MELLITUS.

Mital Bhadania* and Falguni Majmudar

ABSTRACT

Background: This observational study was intended to evaluate safety and effectiveness of metformin Monotherapy with sulphonylureas and pioglitazone in routine clinical practice in type 2 diabetes mellitus. Material and method: This was a 26 week, multicentre, parallel group, open label, non-randomized, observational study carried out in T2DM patients from Gujarat India. Result: A total of 105 subjects with T2DM, mean age 57.28 ± 6.17years and mean duration of diabetes, 2.63 ± 1.83 years were completed study. 82 patients enrolled in age between 51 to 65 years. Metformin combination with sulphonylurea and thiazolidinedione significantly reduced HbA1c%, FBG and PPBG. Triple combination of metformin, sulphonylurea and thiazolidinedione achieved highest percentage of HbA1c% goal at <6.5 and ≤7.0 as well as Fasting and postprandial blood glucose. Among all group percentage minor hypoglycaemic events occurs in dual combination of metformin and thiazolidinedione. Conclusion: In Gujarati people, triple combination therapy with metformin, Sulphonyluea and thiszolidinedione having good glycemic control as compare to dual combination.

Keywords: Diabetes mellitus, HbA1c, glycemic control, sulphonylurea, pioglitazone.


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