WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ACELOFENAC TABLETS

Abhishek Pandey* and Suman Jain

ABSTRACT

Acelofenac (2-{2-[2, 6-Dichlorophenyl) amino phenyl} acetoxy) acetic acid] is diclofenac analog and analgesic drug with bitter taste. Acelofenac is selective COX-2 inhibitor, faster acting superior NSAIDS than other with better GI tolerability. In this study an attempt had been made to formulate fast disintegrating tablets (FDT), of acelofenac with altered taste by using (DC grade) directly compressible grade excipients to enable the formulation directly compressible with adequate mechanical strength. Superdisintegrants like crosspovidone, sodium starch glycolate (SSG), croscarmellose sodium and along with sweeting agent were used in formulation development. The tablets were evaluated for weight variation, hardness, friability, disintegration time, wetting time, in vitro dissolution studies and drug content. It was concluded that the batch prepared by using combination of crosspovidone and sodium starch glycolate as a superdisintigrant shows prominent disintegration time, enhanced dissolution rate.

Keywords: Acelofenac, Fast dissolving tablet (FDT), Wetting time, Superdisintegrant.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More