WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

SOLUBILITY ENHANCEMENT OF TIZANIDINE BY ß- CYCLODEXTRIN SOLID INCLUSION COMPLEXATION TECHNIQUE

*Sucheta D Bhise, Milin R Nand

ABSTRACT

Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at α-2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibres or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. Its poor aqueoussolubility and slow dissolution rate of the drug lead to a lack of dose proportionality and high inter and intrasubject variability. The rationale of this study was to improve the biological performance of the drug by enhancingits solubility and dissolution through complexation with β-CD. In the present study attempt has beenmade to prepare and characterize inclusion complexes of Tizanidine with β-CD and evaluation of release kinetics of the dissolution of solid inclusion complex using different models. The phase solubilityanalysis indicated the formation of 1:1 molar inclusion complex of Tizanidine with β-CD. The apparentstability constant (KC) was 37.85 M-1 for β-CD. The inclusioncomplexes were prepared by three different methods viz. Physical, Kneading and Co-precipitation method. Theprepared complexes were characterized using FT-IR, and Differential Scanning Colorimetry (DSC). The inclusioncomplex prepared with β-CD by Kneading method exhibited significant solubility enhancementand fastest dissolution.

Keywords: ?-CD, Tizanidine, kneading method, inclusion complex, phase solubility studies.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More