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Abstract

FORMULATION AND EVALUATION OF TABLETS CONTAINING POORLY WATER SOLUBLE DRUG BY MADG METHOD.

Devendra Sharma, M.D. Godbole, Ameya Lanjewar* and Sushil Burle

ABSTRACT

Tablet is a unit solid dosage form containing active ingredient with or without suitable excipient. These are most widely used dosage form.[1] The main objective of the design and manufacture of the compressed tablet is to deliver orally correct amount of drug in the proper form over proper time and at desired location, so as to have suitable chemical integrity protected at the point of its action. The physical design, manufacturing process, and complete chemical makeup of the tablet can have a profound effect on the efficiency of the drug being administered.[2] Poorly water soluble drugs are associated with slow drug absorption leading eventually to inadequate and variable bioavailability[3] and nearly 40% of the new chemical entities currently being discovered are poorly water-soluble drugs.[4] Based upon their permeability characteristics, the biopharmaceutics classification system (BCS) classifies such drugs in two major classes, i.e., Class II and IV. The BCS class II drugs are poorly water-soluble entities with high permeability. Most formulation strategies for such drugs are targeted at enhancing their fine dispersion at absorption level.[5] Ibuprofen being poorly water-soluble drug known to demonstrate dissolution or solubility limited absorption. The bioavailability of the drug is low, yet its rate of absorption is quite inconsistent and delayed with time. Based upon its aqueous solubility and various dissolution parameters, the drug bioavailability can unambiguously be regarded as limited solely to dissolution.[6] The main focus on moisture activated dry granulation method is better than other granulation method in case of poorly soluble drug tablets.

Keywords: MADG, Tablets, Ibuprofen.


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