WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

“DEVELOPMENT AND VALIDATION OF NOVEL UV SPECTROSCOPIC ASSAY METHOD OF EZETIMIBE IN BULK DRUGS AND DRUG FORMULATIONS”

Avinash M. Bhagwat*, Anand P. Khadke, Anuradha M. Patil, Sanjana N. Sawakhande, Rucha J. Kulkarni and Snehal V. Tarade

ABSTRACT

This study has done to develop a cheap, reliable and stable method for the drug content determination of ezetimibe from its formulated tablets. A binary reversed-phase (C18-column) high performance liquid chromatograph was used for the analysis. An isocratic method was applied with the mobile phase acetonitrile and water in the ratio of 75:25 (by volume). For detection the ezetimibeanalyte UV-Detector was used at the wavelength 230 nm. The average retention time of ezetimibe was 3.30 min. The flow rate was 1.0 ml/min. The method was linear with regression coefficient (R2= 0.994). The limit of detection (LOD) and limit of quantification (LOQ) were calculated 0.04 and 0.12 μg/ml. Average inter-day and intra-day recovery percentage were computed 98.44% and 99.62% with coefficient variation percentage 3.07 and 0.75%. Recovery results were showed good accuracy of the method. Hence, this method validation was statistically significant.

Keywords: Develop, Validation, RP-HPLC, Ezetimibe.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More