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Abstract

FORMULATION DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF TIZANIDINE HYDROCHLORIDE BY DIRECT COMPRESSION METHOD: FOR THE EFFECTIVE TREATMENT OF MUSCLE SPASM

Amit Kumar*, Sanjay Kumar Sharma, Manish Jaimini, Bhupendra Singh Chauhan

ABSTRACT

The purpose of this research is formulation design and evaluation of fast dissolving tablets of tizanidine hydrochloride by direct compression method. Methods: Tizanidine hydrochloride was used as desired drug for the formulation of fast dissolving tablets. The tablets were prepared using three superdisintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone. Other excipients used in this research were microcrystalline cellulose, talc, magnesium stearate and vanillin. Analytical methods such as UV- spectroscopy and DSC were used for the identification of the pure drug. Formulation blends were evaluated for pre compression parameters such as bulk density, tapped density, Carr’s index Hausner’s ratio and angle of repose. Direct compression method was used to prepare tablets. The prepared tablets were also evaluated for weight uniformity test, hardness, uniformity of thickness, friability test, in-vitro disintegration time, wetting time, water absorption ratio, drug content uniformity, in-vitro dissolution studies and accelerated stability studies. The release data were subjected to different models in order to evaluate their release kinetics and mechanism. Results & discussion: The compatibility study of the prepared tablets implies the information about no interaction between drug and polymers. Within 8 formulations, formulation TZN8 is the best and hence optimized one. Conclusion: After the dissolution study of prepared tizanidine hydrochloride tablets, it was concluded that the formulations TZN8 with crosscarmellose sodium and sodium starch glycolate shows better release and disintegration time than any other.

Keywords: Tizanidine hydrochloride, sodium starch glycolate, crosscarmellose sodium and crospovidone.


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