WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

NOVEL FRONTIERS IN NASO-BRAIN DRUG DELIVERY;CHALLENGES AND OPPORTUNITIES: AN OUTLOOK

Sandeep Kaur, Manoj Kumar Katual*, Radhika Sharma, Gurdeep Kaur, S. L. Harikumar

ABSTRACT

Delivery of drugs through nasal route has been potentially explored as an alternative route for administration of vaccines and bio molecules such as proteins, peptides and non peptide drugs, hence it has attracted the interest of scientific community. Nasal route is beneficial for the drugs which are unstable on oral administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. It is thought that olfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drug from the nose to the brain. This Nasal route is alternative to parentral therapy and also useful for long term therapy. Nasal mucosa is highly vascularised and most permeable giving rapid absorption and onset of action. Nasal route is non invasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives good absorption of small molecules, than that of large molecules can be increased by absorption promoters. In this article is an overview of intranasal drug delivery with its various aspects like factors affecting nasal absorption, strategies to improve bioavailability are discussed.

Keywords: Intranasal drug delivery, Bioavailability, Nano-technology, Permeation enhancers.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More