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Abstract

FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF METRONIDAZOLE 500MG FLOATING TABLETS FOR THE TREATMENT OF HELICOBACTER PYLORI INDUCED GASTRIC INFLAMMATORY DISORDER

Manoj Kumar Katual* and S.L. Harikumar

ABSTRACT

One novel approach in gastro-retentive drug delivery system (GRDDS) is prolonging the gastric retention of the delivery system is some time desirable for achieving therapeutics benefits of drug that are absorbed from the proximal part of the gastro-intestinal tract (GIT) or that is less soluble in or are degraded by the alkaline pH or they encounter at the lower part of the GIT. GRDDS are thus beneficial for such drugs by improving their bioavailability, therapeutics efficacy and possible reduction of the dose. Apart of these advantages, these systems offer various pharmacokinetics advantages like maintenance of constant therapeutic levels over a prolonged period and thus reduction in fluctuation in the therapeutic levels. Dosage forms that can be retained in stomach are called gastro retentive drug delivery systems (GRDDS). GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site thus ensuring its optimal bioavailability. Gastro retentive dosage forms (GRDFs) are designed to be retained in the stomach for a prolonged time and release their active ingredients and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal (GI) tract. This technology has generated enormous attention over the last few decades owing to its potential application to improve the oral delivery of some important drugs for which prolonged retention in the upper GI tract can greatly improve their oral bioavailability and/or heir therapeutic outcome. This research article focus on the simple method for formulation and development of laboratory scale metronidazole 500 mg tablets and evaluated by all quality control parameters.

Keywords: GRDDS, Buoyancy tablets, Floating drug delivery systems.


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