WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

DEVELOPMENT AND VALIDATION OF RP HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ATENOLOL AND CHLORTHALIDONE IN TABLET FORMULATION

Hitesh C. Pimpale, Parag T. Bakshe*, Sachin S. Rane, Prof. (Dr.) Rajesh Y. Chaudhari, Prof. (Dr.) Vijay R. Patil

ABSTRACT

A new simple, rapid, precise and accurate assay method was developed for simultaneous estimation of Atenolol and Chlorthalidone in pure and tablet formulation. The analytes were separated by RP HPLC on a RP-Purosnosphere C18 column (5 μm, 4.6mm* 250 mm). The mobile phase was methanol: water (60:40 v/v) at 1.1 ml/min flow rate satisfactorily resolve the tertiary mixture. The UV detector was operated at 238 nm for the determination of all the drugs. Linearity, accuracy and precision were found to be acceptable over the concentration ranges of 10-160 μg/ml for Atenolol and 5-25 μg/ml for Chlorthalidone with a R2 0.9957 and 0.9965values respectively. The optimized methods proved to be specific, robust and accurate for the quality control of drugs in bulk drug and pharmaceutical formulations.

Keywords: Atenolol, Chlorthalidone, Method Validation, RP HPLC, ICH, C18.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More