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Abstract

DEVELOPMENT AND VALIDATION OF DUAL WAVELENGTH SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND PREDNISOLONE ACETATE IN PHARMACEUTICAL FORMULATION

Bansari D. Patel* and Satish A. Patel

ABSTRACT

The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength method for simultaneous estimation of Ofloxacin and Prednisolone acetate in pharmaceutical formulation. The principle of dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. Ofloxacin was determined directly at 323.40 nm in methanol. The wavelengths selected for determination of Prednisolone acetate were 323.40 nm and 277 nm in methanol. The two drugs follow Beer- Lambert’s law over the concentration range of 3-40 μg/ml. The method was successfully applied to pharmaceutical formulation. The suitability of this method for the quantitative determination of Ofloxacin and Prednisolone acetate was proved by validation. The results of analysis have been validated statistically and by recovery studies according to ICH guidelines.

Keywords: Ofloxacin, Prednisolone acetate, Dual wavelength method, Pharmaceutical formulation, Spectrophotometric, Validation


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