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Abstract

ASSESSMENT OF LUDIFLASH AS A SUPERDISINTEGRANT IN FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET OF FEBUXOSTAT

Deepali B. Rajpure*, Sagar D. Kore, Makarand V. Puri and Parag A. Kulkarni

ABSTRACT

Febuxostat is drug used in the treatment of gout. This drug has very poor bioavailability about 49% due to its poor solubility. The present research work was aimed to minimize these two limitations i.e. poor bioavailability and poor solubility. This research work involves incorporation of β-Cyclodextrin & Ludiflash as excipients to improvise rate of disintegration & solubility of Febuxostat. Assessment of Invitro studies depict that the solubility and dissolution rate of Febuxostat was significantly improved by complexion with β- Cyclodextrin & Ludiflash as a superdisintegrant. The formulation was prepared with β-Cyclodextrin, Ludiflash & other additives by kneading method which exhibit remarkable solubility. The Febuxostat containing tablets was prepared by direct compression method using other ingredients such as kollidon CL-SF, kollidon CL-F, microcrystalline cellulose. The formulation of Ludiflash as a superdisintegrant in the concentration of (20 %) i.e. F4 batch gives best results as this formulation required minimum disintegration time & wetting time as compared to formulations of kollidon CL-F and kollidon CL-SF with same concentration. So it can be conclusively stated that Febuxostat fast disintegrating tablet can be formulate with β- Cyclodextrin & Ludiflash.

Keywords: Febuxostat, ?-Cyclodextrin, Ludiflash, Gout, kollidon CL-SF, Kollidon CLF.


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