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Abstract

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF BENZTHIAZIDE AND TRIAMTERENE IN THEIR COMBINED DOSAGE FORM

Rachita Jain*, Shivani Majithia, Patel Mayur, Reena Chaudhary and Kavita Pareek

ABSTRACT

The RP-HPLC method describes developed simple, rapid, specific, selective, accurate and precise method for the simultaneous estimation of Benzthiazide and Triamterene in tablet form. Benzthiazide falls under the category of Thiazide Diuretic and Antihypertensive Agents whereas Triamterene falls under the category of potassium-sparing diuretic and is used in the management of edema associated with congestive heart failure, hepatic cirrhosis with ascites, nephrotic syndrome, and idiopathic edema. RP-HPLC method for Benzthiazide and Triamterene were developed using mobile phase buffer (pH3.5): methanol (70:30v/v), flow rate 1mL/min, injection volume 20μL, temperature 25 ºC detection wavelength 222nm. Linearity range was found to be 5-15μg/ml for Benzthiazide and 10-30μg/ml for Triamterene. LOD and LOQ values were found to be 1.513 and 4.587 μg/ml for Benzthiazide and 0.695 and 2.108 μg/ml for Triamterene respectively. The assay result found to be 99.75 % and 99.97 % for Benzthiazide and triamterene respectively. The developed method was validated according to ICH guidelines.

Keywords: Benzthiazide, Triamterene, RP-HPLC Method, simultaneous estimation.


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