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Abstract

FORMULATION AND EVALUATION OF STOMACH SPECIFIC DRUG DELIVERY SYSTEM FOR CEFPODOXIME PROXETIL

Jain Sandhyakumari S*, Jaymin Patel and Dr. Shreeraj Shah

ABSTRACT

The objective of the present study was to formulation and evaluation of stomach specific drug delivery system for Cefpodoxime Proxetil. Cefpodoxime Proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of cephalosporin class. Cefpodoxime Proxetil has a short elimination half-life & also possesses high solubility, chemical, enzymatic stability and absorption profile in acidic pH. Cefpodoxime Proxetil floating insitu gel drug delivery system were prepared using Sodium alginate as gelling polymer, HPMC K100M as release retarding (sustained release) polymer and calcium carbonate (CaCo3) as complexing agent using ion sensitive hydrogel approach. A 32 full factorial design was applied to systematically optimize the drug release profile. The concentration of sodium alginate (X1) and concentration of HPMC K100M (X2) were selected as independent variable and gelling strength, floating lag time & time required for complete release (T100) were selected as dependent variable. The optimize batch was obtained is F9 showed statisfactory results with respect to viscosity, floating lag time, total floating duration & sustained drug release properties.

Keywords: Floating in situ gel, sustained release, Cepfodoxime Proxetil, Ion sensitive hydrogel, sodium alginate, HPMC, 32 Full factorial design.


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