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Kadiri Sunil kumar*, R.Suthakaran, Kalakonda rajesh, B.K. Jaya Lakshmi, Mohd.Wajid


The rationale of the present study was to assess gastroprotective activity of plant celosia argentea (200mg/kg) methanolic leaf extract against swimming stress induced ulcers in rats. Celosia argentea plant is known as troublesome weed in india and china. Gastric ulcers were induced in rats by forcing the animals to swim inside a vertical cylinder containing water up to 15 cm height for a period of 3hrs. Methanolic extract of the leaves of celosia argentea plant (200mg/kg) was administered to wistar rats orally 60 minutes prior to swimming test. After 3hrs of swimming period, the rats were sacrificed by decapitation method and the stomachs were removed and observed under compound microscope undex 10X magnification for the presence of ulcers. Ulcer incidence and severity were quantified by an ulcer index. Rats pretreated with celosia argentea (200mg/kg) had shown a significantly lower ulcer index 1.5±0.31than control rats with ulcer index 3.81± 0.73. Standard (lansoprazole 30mg/kg, p.o) treated rats has shown an ulcer index of 0.13 ± 0.51. Methanolic extract of celosia argentea leaf has shown a significant reduction in ulcer index with an ulcer inhibition up to 60.62%. Whereas standard lansoprazole has exhibited ulcer inhibition up to 96.58%. Phytochemical studies indicated the presence of flavonoids, glycosides, alkaloids, cardenolides and phenolics in celosia argentea leaves1. Hence the present antiulcer activity of celosia argentea leaves may be attributed to these chemical constituents.

Keywords: celosia argentea, swimming stress, gastro protective activity

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