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Abstract

FREE RADICAL SCAVENGING ACTIVITY OF LEAF AND CALLUS EXTRACT OF PERGULARIA DAEMIA (FORSSK.) CHIOV. IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

P. Vinoth Kumar and N. Ramesh*

ABSTRACT

The GPx activity was significantly lower in diabetic rats treated with the various leaf extract of P. daemia (P< 0.05) compared to control diabetic rats. GSH concentration was significantly lower in diabetic control rats compared to the treated diabetic and normal rats (P< 0.05). The GST activity was significantly lower in diabetic rats treated with the various leaf extract of P. daemia (P< 0.05) compared to control diabetic rats. The activities of SOD, CAT, and TBARS were significantly lower in diabetic rats treated with leaf extracts compared to control diabetic rats (P< 0.05). The HPx level was significantly higher in diabetic control rats compared to the treated diabetic and normal rats (P< 0.05). There was no significant difference among the normal and control groups. A significantly elevated level was observed in diabetic control rats and those treated with ethanol callus extract when compared with diabetic rats treated with the ethanolic, aqueous, chloroform leaf extract and the normal groups. However, the enzymatic antioxidant in liver of diabetic rats treated with the ethanolic callus extract was higher than that of other extracts.

Keywords: P. daemia, liver, chloroform.


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