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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

SYNTHESIS AND CHARACTERISATION OF BENZO(H)CHROMEN- 2-ONE3-METHYL CARBOXYLATE USING PHOSPHOTUNGSTICACID (H3PW12O40) AS AN EFFECTIVE CATALYST AND STUDY ITS ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES

*Anna R. Anthony, Abhay Choudhary, Shrikant Gajbhiye and A. S. Bobade

ABSTRACT

Coumarins and their derivatives are very important organic compounds, They are biologically active and widely occur in nature. They are the structural unit of several natural products. Their applications range from pharmaceuticals, optical brighteners, and laser dyes. Also, coumarins and functionalized coumarins have shown activity as antimicrobials and chemotherapeutics. Some Coumarin derivatives have been widely used as an important chemical in perfume, cosmetic as well as pharmaceutical industrial preparation. Coumarins act as in intermediate for the synthesis of various biologically active molecule such as coumarones, and fluorocoumarins. These properties have made coumarins interesting targets for organic chemists. Thus the synthesis of coumarins is of continuing interest. Phosphotungsticacid (H3PW12O40) is a heteropoly acid environmentally benign non-toxic widely used heterogeneous catalyst. It is the strong acid of the hetero poly acid. The hetropoly anion (PW12O40-3keggin unit) represent the structure of HPW, has been investigated by Jalil.et al using different spectroscopic and chemical techniques such as X-ray diffraction studies (XRD) and infrared (IR) spectroscopy indicated the acid stability and Izumi et al reported HPW molecule is highly stable up to 600oC. This paper focuses is to develop environment friendly reactions, simple, highly efficient and high yielding protocol for the synthesis of Benzo(h)chromen-2-one3-methyl carboxylate using a Phosphotungsticacid (H3PW12O40) as catalyst. This compound showed antimicrobial and anti oxidant properties.

Keywords: Anti microbial, antioxidant Phosphotungsticacid, microwave irradiation.


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