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Jessy Shaji* and Seema Darade


The objective of the present study was to investigate the combined effect of three independent variables in the fabrication of Piroxicam monoethanolamine (PRX-MEA) loaded gold nanoparticles (PMAuNPs) using a 23 full factorial design. PM-AuNPs were prepared by green chemistry approach using methanolic green tea (Camellia. sinesis) extract with factors viz. gold salt concentration X1 (1.57 to 3.93 mg), PRX-MEA concentration X2 (2.86 to 8.12 mg) and reaction time X3 (60 to 180 min.) and were evaluated for their particle Size Y1 (nm) and % loading efficiency Y2 (% LE). The mean particle size of PM-AuNPs batches ranged between 43 to 158.3 nm. Preliminary trials of PM-AuNPs revealed that on increasing the gold salt concentration the particle size was also increased. The % LE was found to be between 81.94 % to 97.78%. Process variables such as gold salt and PRX-MEA concentration had positive impact on percent drug loading efficiency. The effects of all the tested independent variables were significant (P-values<0.05).Using design check point analysis the optimum formulation comprising of 1.96 mg of gold salt, 6.58mg of PRX-MEA and stirring time of 180 min was selected. This formulation demonstrated particle size of 51.02 ± 45 nm and LE of 88.05 ± 0.36 %. PM-AuNPs with small particle size and excellent loading efficiency were successfully produced using this method. Characterization of optimum formulation by evaluating the experimental data showed no significant difference between predicted and observed values.

Keywords: 23 full factorial design, loading efficiency (%LE), Gold nanoparticles, Optimization, Piroxicam Monoethanolamine (PRX-MEA).

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