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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ANTIFUNGAL PRONIOSOMAL GEL FOR TOPICAL APPLICATION

*Preeti Pal and Dr. Saurabh Mishra (Asst. Prof.)

ABSTRACT

The purpose of present research work was to formulate the antifungal Proniosomal gel of Terbinafine hydrochloride with the aim to prolonged drug action and also to overcome the demerits of liposomes and niosomes. In this research work Proniosomal gel was formulated by using Terbinafine hydrochloride as antifungal drug, span 40 and lecithin as a penetration enhancer, cholesterol as a stabilizer and ethanol solvent as solubilizer. Total nine formulations of Proniosomal gel were prepared. The formulated Proniosomal gel was evaluated for the different parameters such as physical characterization, pH, spreadability, viscosity, entrapment efficiency, In-vitro drug release, vesicles size and shape and stability. The formulation F5 out of nine formulations was selected as optimized formulation, which showed the highest % entrapment efficiency (90.54±1.3%), prolonged drug release (66.6±0.9) in 24 hrs. The vesicles formed were in spherical shape identified by optical microscopy. The optimized formulation (F5) was stable for one month of time period. FTIR results showed that there was no interaction between the drug and excipients. Proniosomal gel can be used for the prolonged and localized action of drugs.

Keywords: colloidal drug delivery systems, niosomes, liposomes, antifungal drug, topical drug delivery systems.


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