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Abstract

FORMULATION AND IN VITRO EVALUATION OF ZIDOVUDINE MATRIX TABLETS

B. Deepika, Samrin Begum*, Faria Tahseen, D. Mounika, G. Sri Vyshnavi, D. Shiva Shanker Prasad, Naga Raju Kandukoori, KNV Rao and K. Rajeswar Dutt

ABSTRACT

Zidovudine is Nucleoside Reverse transcriptase inhibitor and widely used in treatment of ART. In present study Zidovudine matrix tablets were formulated and evaluated using various natural and synthetic polymers. Sustained release matrix tablets were prepared by using HPMC k15m, Eudragit S100, Xanthan gum and Guar gum alone as rate controlling polymers by using direct compression method. Total four formulations were developed with 1: 0.25 drug polymer ratio. All the prepared tablets were evaluated for thickness, hardness, friability, weight variation, assay and in vitro drug release studies. From the data it was concluded that the formulations containing Eudragit shown 97% drug release within 12 hours.

Keywords: Zidovudine, Matrix tablets, Eudragit, HPMC K15M.


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