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Abstract

FORMULATION AND EVALUATION OF DICLOFENAC SODIUM MATRIX TABLET BY USING VIGNA MUNGO SEEDS GUM AS A NOVEL MATRIX FORMING AGENT

Sachin Popalghat, *Rahul Sarode and Umesh Joshi

ABSTRACT

The aim of present study was to prepare matrix tablet of diclofenac sodium by using vigna mungo seed gum as a natural polymer. The vigna mungo seed gum which was previously extracted, isolated from vigna mungo seeds and it was exposed to various phytochemical characterizations. The matrix tablet of diclofenac sodium was prepared by direct compression along with the various excipients like HPMC, VMSG, starch, magnesium stearate and talc. Five batches of formulation were prepared by direct compression along with various evaluation parameter such as thickness, hardness, weight variation, friability, drug content and in vitro dissolution study. By studying all the evaluation parameter it was found that batch F2 is optimized batch by In-vitro drug release for 12 hrs. With the release of the 95.03% of drug from the formulation. By performing all the studies it was concluded that 10% HPMC same as 40% VMSG results showed that the selected gum exhibited good matrix forming properties in the In-vitro studies and could be able to control the release same as HPMC. As the concentration of polymer increased the release rate of the drug from formulation was decreased respectively. The DSC and FTIR studies reveals that there is no chemical interaction between the drug and excipients, and from XRD and SEM studies it was confirmed that polymer is amorphous in nature.

Keywords: HPMC, VMSG.


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