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Abstract

“PREPARATION AND CHARACTERIZATION OF HERBAL SOLID DOSAGE FORM FOR ANTI DIABETIC ACTIVITY”

Sachinkumar Pandey*, Trupti Powar and Dr. Sachin Patil

ABSTRACT

The present work aims to investigate the anti-diabetic effects of Mimosa pudica linn and Curcuma longa. The ethanolic extract of dried leaves of Mimosa pudica was evaluated for its antidiabetic activity. Phytochemical screening including qualitative chemical examinations was also carried out. Herbal sublingual tablets of extract of Mimosa leaves, curcuma longa and both in combination were formulated and evaluated for anti-diabetic activity. The tablets were prepared by direct compression method and comparative study was performed. The results of physicochemical parameters and pre-compression studies revealed that all the values were within the acceptable limit. The formulated tablets were evaluated for weight variation, friability, hardness, disintegration time as well as studied for drug release. Batch „C‟ was optimized because it has exhibited good wetting time, water absorption ratio, faster disintegration time and in-vitro dispersion time when compared to other formulations. Results of all the evaluated parameters of the formulated tablets were found to be within the pharmacopoeial limits. The stability studies of optimized batch (Batches „C‟) tablets were conducted for 90 days as per ICH guidelines and were found to be stable.

Keywords: Mimosa pudica linn, Curcuma longa.


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