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Abstract

DEVELOPMENT AND IN-VITRO EVALUATION OF PULSATILE CORE IN CUP TABLET OF TORSEMIDE

Jyosthna Polishetti*, Jyothsna Savula, Praveen Gogu and Swetha G.

ABSTRACT

Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Torsemide is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. The aim of the present work is to prepare and evaluate pulsatile drug delivery system to increase the therapeutic efficacy of torsemide. The drug torsemide is with short half life i.e.3.5 hrs and when it is developed into core in cup type of tablet its half life is extended to 12 hr and when compared to the other drugs like furosemide which is modified to form torsemide is taken 200mg but torsemide is taken as only 25mg with high solubility than furosemide. Core in cup tablet shows zero order kinetics which is an advantage to this type of tablet. The concentration of soluble hydrophilic layer is selected using 32 factorial designs. A typical pulsatile release is obtained from all the formulation with no drug release in the lag time and the concentration of polymer on top layer is a critical factor influencing the release pattern. The core-in-cup tablets were compared with core only tablets and immediate release capsules.

Keywords: Toresemide, pulsatile, core in cup, zero order kinetics, polymer, half life.


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