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Abstract

A PROSPECTIVE STUDY OF PREVALENCE AND ASSOCIATION OF PERIPHERAL NEUROPATHY IN INDIAN PATIENTS WITH NEWLY DIAGNOSED TYPE 2 DIABETES MELLITUS.

Sravani, B.V.S. Lakshmi*, Vishala Nanduri and M. Sudhakar

ABSTRACT

Background: Diabetic peripheral neuropathy (DPN) predisposes to foot ulceration and gangrene. It has been reported that DPN is lower in Indians relative to Caucasians. Studies among recent onset patients with type 2 diabetes mellitus (T2DM) are very few. We studied the prevalence and risk factors of DPN in patients with newly diagnosed T2DM. Individuals with diabetes have reduced HRQoL compared with those without diabetes in the same age group and their HRQoL decreases with disease progression and complications. Materials and Methods: We prospectively studied 80 consecutive patients over age 30 with a duration of diabetes ≤1 year. All underwent a clinical and biochemical evaluation and were screened for DPN using TCSS scale (Toronto clinical scoring system) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale. Health related QOL questionnaires like the individual EQ-5D dimensions and the EQ-5D index was used to obtain the data regarding the impact of Diabetic Neuropathy complication on the patient’s quality of life. Results: The cases had a mean age of 60.28 years and duration of symptoms of DM is 1 year prior to presentation. The overall prevalence of DPN was 12.5%. The prevalence of DPN showed an increasing trend with FBS (trend chi-square= 3.517, P = 0.0304). A logistic regression analysis showed that DPN was independently associated with Fasting Blood Sugar (P = 0.0304), Body mass index (P= 0.0389), HbA1c (P = 0.0451), family history (P= 0.0426) and physical activity (P= 0.0219) but not with age, sex and education. Conclusions: Our study showed high prevalence of PN in recently diagnosed patients with T2DM, which was independently associated with age and duration of symptoms of diabetes prior to the diagnosis. FBS, HbA1c, BMI, family history, physical activity were found to be risk factors for prevalence of Diabetic Neuropathy. Patients with Neuropathy also experience negative impact on QOL in many aspects such as mobility, self-care, pain, anxiety and usual activities. Screening for DPN at diagnosis of diabetes is warranted, especially among older subjects.

Keywords: Diabetic Peripheral Neuropathy, Newly Diagnosed, Type 2 Diabetes Mellitus, Quality of Life.


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