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Abstract

Q-ABSORBANCE RATIO METHOD FOR SIMULTANEOUS DETERMINATION OF SIMVASTATIN AND LOSARTAN POTASSIUM IN SYNTHETIC MIXTURE

Patel Ronak H.* and Patel Paresh U.

ABSTRACT

A simple and sensitive spectrophotometric method based on Q - absorbance ratio was developed for the simultaneous estimation of Simvastatin and Losartan Potassium in pharmaceutical synthetic mixture. Q - absorbance ratio method based on formation of Qabsorbance equation at two wavelengths, one is isoabsorptive point and another is the λ-max of one of the two drugs. Absorbance are measured at two selected wavelengths, one is 248.5 nm (isoabsorptive point) and another being 237 nm (λ-max of SIMVA). The two drugs comply with beer lambert’s law over the linearity range of 3-22 μg/ml. The method was validated as per ICH guideline rules in terms of linearity, accuracy (recovery study), precision (repeatability, intraday, interday validation), limit of detection, limit of quantification. All the validation parameters were found to be within acceptable limits. The method was found to be simple, sensitive, rapid, cost effective, accurate and precise for the routine analysis of both the drugs in the binary mixture.

Keywords: Simvastatin, Losartan Potassium, Q - absorbance ratio method, Binary mixture, Validation.


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