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Abstract

VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF MEMANTINE HYDROCHLORIDE IN PURE AND TABLET DOSAGE FORM BY USING DIFFERENT CHROMOGENIC REAGENTS

S.K. Naffiz, S.D. Ameena, M. M. Eswarudu*, P. Srinivasa Babu, M. Raja Kumari, P. Sindhuja and P. Gouthami

ABSTRACT

Memantine hydrochloride is a new member of the adamantane family and likewise, it shares the non-chromophoric structural feature characterizing these compounds. It is approved for the treatment of moderate to severe Alzheimer's disease. In this work, we present two simple and sensitive spectrophotometric methods for its determination. Method I is based on forming a coloured binary complex with Bromocresol Green (BCG) in potassium hydrogen phthalate buffer (PH 3) which are extracted into chloroform and have absorption maxima measured at 420 nm, while method II uses its reaction with picric acid in chloroform to form a yellow coloured ion pair complex. Which are extracted in the chloroform and have measured at 430 nm. Regression analysis showed good linearity over the concentration ranges of 3-18 and 5-30 μg/mL for method I and II respectively with correlation coefficient values >0.999. The applicability of the proposed methods was evaluated through the analysis of tablets and satisfactory recoveries were obtained. Moreover, the statistical comparison of the obtained results with those of the reference method revealed no significant differences. Thus, the simplicity and high sensitivity of the proposed methodologies can verify their suitability for the routine analysis of memantine hydrochloride in its tablet formulations.

Keywords: Memantine Hcl, Bromocresol Green, Picric Acid and Validation.


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