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Abstract

ABSORBANCE CORRECTION SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND TELMISARTAN IN SYNTHETIC MIXTURE

Ankit B. Patel* and Dipti B. Patel

ABSTRACT

A new, simple, accurate and sensitive UV ‐ spectrophotometric absorpt ion correction method has been developed for simultaneous determinat ion of Simvastatin and Telmisartan in synthetic mixture. Methanol was used solvents. The method is based upon determination of Simvastatin at 237nm and Telmisartan 296nm, respectively. Beer’s law obeyed the concentration range of 3- 18 μg/ ml for both drugs. The percentage recovery was found in the range of 100.06-101.01% for Simvastatin and 100.6-101.4% for Telmisartan. The developed method was validated statistically and by recovery studies. The % RSD value was found to be less than 2. Thus the proposed method was simple, precise, economic, rapid and accurate and can be successfully applied for simultaneous determination of Simvastatin and Telmisartan in synthetic mixture.

Keywords: Simvastatin, Telmisartan, Absorbance Correction.


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