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Abstract

“DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SAROGLITAZAR IN BULK AND PHARMACEUTICAL DOSAGE FORM”

Pathak Hetalkumari*, Dr. Shobha Manjunath and Ravi Ranjan Kumar Pandey

ABSTRACT

A new, simple, precise, accurate, reproducible, economical and sensitive UV ‐ Spectrophotometric method has been developed for the estimation of Saroglitazar in bulk and pharmaceutical dosage form. Saroglitazar was dissolved in methanol-water system in the ratio of 50:50 and exhibited absorption maximum at 293 nm with mean recovery of 100.3%. The drug follows Beer’s Law in the concentration range of 2-12 μg/ml. The LOD and LOQ were found to be 0.29μg/ml and 0.88μg/ml respectively. Methanol-Water was used as solvent. The validation of method was carried out as per ICH Guidelines.

Keywords: Saroglitazar, UV Spectrophotometric method, Validation, LIPAGLYN Marketed formulation.


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