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Abstract

SELF-EMULSIFYING DRUG DELIVERY SYSTEM

Shivaji Talegave*

ABSTRACT

Self- emulsifying drug delivery system are the unique mixture of oil, solvent surfactant, co-surfactant, co-solvents. These are the effective approach to solving the solubility of poorly soluble drug. From couple of years aqueous solubility is biggest issues to the formulator for formulation and development of novel drug delivery. SEDDSs are Good strategy for enhancement of oral absorption and bioavailability of BCS class 2 and class 4 drugs. For these system oral route is most convenient than other route. Requirement of this system is due to poor solubility and oral absorption of highly lipid soluble drug. Those drug which is formulated by SEDDS will have good pharmaceutical market. These system have ability to form emulsification with the solid as well as liquid dosage form .SEDDS are very quickly dispersed in the gastro-intestinal fluid and making micro or Nano-emulsion containing solubilized drug. These article covers formulation, Evaluation, future aspect and application part of self-emulsifying drug delivery system.

Keywords: Self Emulsifying Drug Delivery System (SEDDS), Solubility, bioavailability


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