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Abstract

FORMULATION AND EVALUATION OF TOPICAL NIOSOMAL GEL OF ROXITHROMYCIN

*Apurva saxena, Vishal kapoor, Dr M.D Bharti

ABSTRACT

Roxithromycin is a macrolide antibiotic,which is used commonly for the treatment of soft tissue infection either single or in combination. Niosomes, a vesicular formulation, has been explored extensively for topicalapplication to enhance skin penetration as well as to improve skin retention of drugs. In the present investigation, Roxithromycin was entrapped intoniosomes by a thin film hydration technique and various process parameters were optimized by partial factorial design. The optimized niosomalformulation was incorporated into carbopol gel and extensively characterized to Percentage Drug Entrapment (PDE) and inā€vitro releaseperformance. The stability of above formulation was studied at different temperatures. The present study demonstrates prolongation of drug release after encapsulation of Erythromycin intoniosomal topical gel

Keywords: Soft tissue infection, Roxithromycin, Macrolide antibiotic,Niosomal gel.


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