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Abstract

SYNTHESIS CHARACTERIZATIONS & EVALUATIONS OF NEW ANTIMICROBIALS

Yogesh Kumar Sharma* and Prof. (Dr.) Rakesh Kumar Jat

ABSTRACT

Antibiotics are agents produced by microorganisms, which suppress the growth of or kill other microorganisms at very low concentrations. The term antimicrobial agent is used to designate synthetic as well as naturally obtained drugs that inhibit the growth of microorganisms. The use of antimicrobial drugs in human medicine has resulted in spectacular gains in human health and life expectancy. The main objective of the present study is to develop new chemical entities with potential antibacterial, which are superior to the currently available drugs and also which has an improved spectrum of activity even towards the most resistant organisms. So, in the introduction currently available anti-tubercular agents, antibacterial agents, antifungal agent’s problems associated with the current therapy and current trends in the field of anti-microbial research On the biases of target based approach for the synthesis of new drugs by which a sufficient grade of selectivity can be achieved for anti-microbial activity. Various new molecules were synthesized by using bezothiazoles nucleus. After biological evolutions it was found that (8a-i) (Benz) exhibited antibacterial activity at tested concentration less 1000μg/ml, After characterization & biological evaluation it was found that the some compound of benzothiazole 8d(Benz) exhibited activity at lower concentration <20 μg/ml. & the Compounds like 8h(Benz), was not exhibited activity higher concentration up to 1000 μg/ml against both gram positive and gram negative organisms.

Keywords: Improved spectrum of activity Microorganisms are becoming resistant Need for the development Excessive metabolism of the drug Increased efflux of drug.


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