WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EVALUATION OF THE BINDING PROPERTY OF SIDA ACUTA GUM IN PARACETAMOL TABLET FORMULATIONS

Okafo Sinodukoo Eziuzo* and Chukwu Amarauche

ABSTRACT

The study was done to evaluate the binding property of different concentrations of Sida acuta gum (SAG) in paracetamol tablet formulations and to compare it to standard gums. SAG was extracted from powdered dried leaves of Sida acuta macerated in distilled water. Paracetamol tablets were prepared by wet granulation using SAG (0 - 2%), Corn starch mucilage (1.5 -2%) and hydroxypropylmethylcellulose, HPMC (1.5 -2%) as binders respectively. They were evaluated based on official and unofficial tests. The paracetamol granules showed passable to excellent flow property. The tablets have hardness values from 3.5 ± 0.00 to 6.75 ± 0.35 Kgf (SAG), 3.75 ± 0.35 to 4.0 ± 1.41 Kgf (starch mucilage), 2.75 ± 0.35 to 3.5 ± 0.00 Kgf (HPMC) and 0.35 Kgf (0 % binder). Tablet friability was less than 1 % for all formulations except P9 (3.18 %) that contained no binder. The % weight deviation for all the formulations ranged from 0.00 to 3.33%. The disintegration time (min) for the tablets ranged from 6.33 ± 5.86 to 49.00 ± 1.00 (SAG), 1.39 ± 0.10 to 1.53 ± 0.13 (Starch mucilage), 0.49 ± 0.08 to 0.79 ± 0.04 (HPMC) and 0.50 ± 0.00 (zero binder). The drug content of the formulations was found to be between 97.2 to 102 %. All the formulations released more than 75 % of their drug contents within 45 min. The binding property of SAG in paracetamol tablet formulations increases with increase in concentration.

Keywords: Binding property, paracetamol, Sida acuta gum, tablets, evaluation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More