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Abstract

HEPATOTOXIC VS NEPHROTOXIC POTENTIAL OF CHLORPYRIFOS ON SWISS ALBINO MICE

Ranjit Kumar*, Surbhi Kumari, Anamika Kumari, Md Ali1, Arun Kumar, A. Nath and J.K. Singh

ABSTRACT

Pesticides have numerous beneficial effects. These include crop protection, preservation of food and materials and prevention of vector-borne diseases. Chlorpyrifos is still widely used pesticide for crops and farm animals. It induces toxicity through inhibition of acetyl cholinesterase. Thus the present study is designed to evaluate hepatotoxic Vs nephrotoxic potential of Chlorpyrifos on Swiss albino mice. chlorpyrifos was administered at 6 mg/kg b.wt dose for 4 weeks by Gavage method. Sacrifice was done on1st week, 2nd week and 4th week of chlorpyrifos administration in each group. Urea and Uric acid were increases with increased duration of chlorpyrifos exposure. Degeneration was observed in hepatic cells and hepatic veins. Glomerulus and bowmens capsule were also degenerated. Thus it is concluded from study that chlorpyrifos causes degenerative changes in both liver and kidney, but it causes more degeneration of glomerulus and bowmens capsule. Degeneration of cytoplasm of PCT and DCT are frequent than cytoplasm of hepatic cells. It is evident from study that chlorpyrifos is more neprotoxic than hepatotoxic

Keywords: Hepatotoxicity, nephrotoxicity, glomerulus, bowmens capsule.


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