Abstract

THE EFFECT OF ETHANOLIC PULP EXTRACT OF ADANSONIA DIGITATA IN HYPERLIPIDEMIC EXPERIMENTAL ALBINO RATS

Nawar Ahmed Mohammed, Tarig Mohamed Fadl Elmula and Ayman Ali Mohammed Alameen*

ABSTRACT

Background: Hyperlipidemia represents several different disorders of lipid metabolism related to increased production, delayed degradation of atherogenic lipoproteins particles, or decreased synthesis. Such metabolic arrangements of lipoproteins are associated with serious health consequences including increase risk of atherosclerosis and its related disorders. Digitata extract has ability to reduce the hyperlipidemia this due to presence of pectin fiber, which is fermented in colon. Pectin may help lower plasma and liver cholesterol, triglycerides and LDL either by inhibition of cholesterol and bile acid absorption or due to increase excretion of this natural and acidic sterols. This study aimed to see the effect of Adansonia Digitata extract on lipid level in experimental Albino Rats. Methodology: It is experimental study performed on 25 albino rats weigh 150 – 200 gm. 20 of them where induced for hyperlipidemia by cholesterol powder mixed with butter for two weeks. Adansonia Digitata extract in 70% ethanol, used as hypolipidemic herb in hyperlipidemic Albino rats. Different concentrations of it used including; high dose 3.75 g/ kg, medium dose 2.5 mg / kg and low dose 1.25 mg/ kg. A group of hyperlipidemic rats treated with the hypolipidemic drug (atorvastatin 10 mg), other group of rats used as negative control. Samples were collected after 12 hours of fasting from hyperlipidemic rats treated with extract of A. Digitata and the control groups. Lipid profile measurement after standardized meal, doses of Digitata extract, and hypolipidemic drug performed. Result: Adansonia Digitata reduce level of lipids with different doses. The high dose 3.75 g/kg shows highly significant decrease in total serum cholesterol, triglycerides, LDL (P. values = 0.001, 0.039, 0.000 respectively), also significant decrease observed in low dose also (1.5 g / kg) (P. values = 0.025, 0.010, 0.039 respectively. Conclusion: Adansonia Digitata suitable to be used as natural hypolipidemic agent.

Keywords: Adansonia Digitata, Hyperlipidemia, Cholesterol powder, Butter, Atorvastatin.