COCRYSTALLIZATION TECHNIQUES FOR ENHANCEMENT OF SOLUBILITY
Rani M. Umate*, Gouri R. Dixit, Kanchan P. Upadhye, Suparna S. Bakhale, Chetna S. Dakhate and Anup R. Thakre
ABSTRACT
The aim of this review is focused on the improvement of the solubility
and bioavailability of poorly soluble drugs by using Crystal
engineering approaches. Therapeutic effectiveness of a drug depends
upon the bioavailability and ultimately upon the solubility of drug
molecules especially in oral formulation. So many times it becomes
challenging to formulate poorly water soluble drugs. Therefore it is
necessary to improve solubility of drug by methods like co-solvency,
salt formation, addition of solubilizing agent, micronization
complexation, solid dispersion etc. A pharmaceutical co-crystal is a
novel approach where single crystalline solid incorporates two neutral
molecules, one being an active pharmaceutical ingredient (API) and
the other a co-crystal former. Pharmaceutical co-crystals are nonionic
supramolecular complexes and can be used to address physical
property issues such as solubility, taste masking. This review cover the co-crystallization,
techniques, properties and application in pharmaceutics.
Keywords: Bioavailability, BCS-II Cocrystal, Conformer, Solubility, Salt formation.
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