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Abstract

FORMULATION AND EVALUATION OF SERRATIOPEPTIDASE MICROSPHERES USING EUDRAGIT RS100 POLYMER

Nitin Narayan Hire*, Amol Bhalchandra Deore, Dilip Vishram Derle , Kiran Ramesh Nathe

ABSTRACT

Inflammation is nature’s double-edged sword, characterized by pain and swelling, is triggered as a healing response in the body when it is injured or attacked by negative bacteria and viruses. Once the body recovers, the inflammation goes away. However, for tens of millions of worldwide, with disorders such as rheumatoid arthritis, sinusitis, bronchitis, fibrocystic breast disease, and carpal tunnel syndrome, the inflammation does not go away. The conventional treatment for inflammation disorders also has dark side serious side effects. Fortunately, there is a natural medicine serratiopeptidase used as an effective alternative to steroids and NSAIDs without serious side effects. Serratiopeptidase is acid labile drug thereby decreasing stability in gastrointestinal tract. It is protein in nature and claimed to be effective orally but due to its large molecular size show reduction in bioavailability. Therefore to reduce frequency of dosing as well as to increase bioavailability and enable better compliance, formulating sustained release dosage form is necessary. Serratiopeptidase microspheres have been formulated by emulsion solvent evaporation technique using polymer Eudragit RS100 and evaluated for possible antiinflammatory potential.

Keywords: Eudragit RS100, Serratiopeptidase, bioavailability, microspheres, antiinflammatory activity.


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